Four Ways To Prevent Your Electric Bicycle From Being Stolen ...

If you have just bought an electric bike, you should pay attention to the safety of the electric bike. Criminals prefer to steal new electric bikes because these new bikes can be sold at a very good price. Therefore, when riding your new electric bikes to go somewhere, you should lock your electric bicycle well. According to some studies, most of the owners do not pay much attention to the lock of the electric bike and that is why their bikes are easily stolen by the criminals. In this article I will state four useful tips suggested by the expert.

First, when you want to stop and lock your electric bike, you had better choose some place where there are some people or have lights. Generally, the criminals are not dared to steal the bikes in these places. But if you stop the electric bicycle in some remote places, it will be stolen easily.

Second, do not think that if you store the electric bikes in the garage, you can leave the electric bike unlocked. Sometimes, the criminals can break into your garage and steal the electric bike. Therefore, when you stop your bike in your garage, you also need to lock the bike to prepare for all contingencies.

Third, when choosing the locks, you should choose the high quality locks. Nowadays, as the development of technology, the thieves have more and more advanced ways to unlock your locks. Therefore, some high quality locks can prevent stealing.

Fourth, if condition permit, you had better weld the electric bicycle battery and the electric bike together. There are some thieves that only steal the batteries which are also expensive.

At last, when you find that your electric bicycles have been stolen, you need to report to the policeman as soon as possible.

Source: http://recreationandsports.therefinedgeek.com.au/index.php/2011/10/four-ways-to-prevent-your-electric-bicycle-from-being-stolen/

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Pc Gaming Chair | New Gamer PC - Where your PC games ...

Pc Gaming Chair

In the different range of gaming chairs pc gaming chair is one of the most relaxing and durable chair. Most of the people spend long hours in front of the pc, which is very stressful process for the body so for this purpose gaming chair is better option and provide comfortable and relaxing seating in front of the pc while playing your game and or working in your office etc. The pc gamers prefer the pc gaming chair for their long sessions of their games.
Feautures and categories in Pc Gaming Chair

The pc gaming chair is one of the most durable and valued chairs for the comfortable fabric and good use of material. Pc gaming chair with three levers provides better control of positioning for back seating. It is available either office or home no matter the decent pc gaming chair is available for economical reasons prices. Pc gaming chair for different age group with full rand features and digital selector, LCD display full range of speakers facilitates you. The type of gamer either lazy audiophile or others will love the pc gaming chair. The adjustment of tiling seat with pc gaming chair and use of speaker is also very famous among the gamers. The wireless pc gaming chair is also providing different interesting features.
Multiple stylish designs and uses of Pc Gaming Chair

The pc gaming chair provides your knees and back comfort of sitting and remove the stress from you body parts. It supports the back needs and is very good for ventilation. The beautiful look and durable quality is very famous in the pc gaming chair. The pc gaming chair is even compared with the aero gaming chairs which very expensive than it. The almost equal quality or we can say that pc gaming chair is better comparatively in different aspects.
How to get Pc Gaming Chair?

You can get your pc gaming chair from different stores in different stores in very low prices and better quality product with more durability. Pc gaming chair with product description, product detail and information about available features are provided. In the websites the online shopping is the better way to choose for different products. The online shipping is also provided by different stores for pc gaming chair. The shipping option is mostly free. The higher quality with warranty you can get pc gaming chair very easily with wide variety of product features

Source: http://newgamerpc.com/pc-games/pc-gaming-chair/

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Personal Finance Software is Important in Keeping People ...

A lot goes on in the financial part of a person?s life. People should organize all their financial information and personal expenditures. This is a lot to do and many lose track of much it.

Unfortunately, many people drop the ball on the finances part which can get them into trouble. Maintaining and organizing finances is important to a person?s financial and emotional well-being.

People often use personal finance software that helps keep track of money. However, many of these personal finance software programs only track and balance a checkbook and a monthly budget. A person inputs all monthly bills and dates they are to be paid. The program sends out reminders to pay the bills. This software also has a person input checks and ATM withdraws to balance the account and ideally will prevent overdraws on their account.

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The problem with this type of personal finance software is that it is not comprehensive enough. In fact it is not really personal finance software because it only deals with a checking and savings account. Much more information goes into a person?s finances than that. A good personal finance software covers various financial areas.

One important area it manages and organizes is a person?s investments. Typically these investments would be stocks, bonds, and a 401K. Stocks especially should be monitored closely in today?s volatile economy.

Quality personal finance software also allows a person to organize their mortgage and other loans they may have. It is also useful for those people looking to buy a home as well. Finding the best mortgage rates is almost automatic with good software.

Personal finance software offers a wide range on other financial monitoring services. These include taxes, credit reporting, personal financial statements and retirement planning. These services are helpful to just about everyone is some way or another.

Personal Finance Software is a company which offers this software as a free service. To find more information visit their website at www.personalfinancesoftware.com.

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About Author:

PersonalFinanceSoftware provides free financial calculators, online finance software, business software and budgeting software. It is available online for 24/7. Their software can be used on Windows, MacOS X and Linux operating systems. For more details visit:

http://www.personalfinancesoftware.com/

Find More Personal Finance Articles

Source: http://www.adjunctwork.com/2011/10/personal-finance-software-is-important-in-keeping-people-financially-organized/

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Touch your target market directly with SMS ... - As Seen On Cell Phone

Touch your target market directly with SMS marketing

The popularity of SMS as a marketing tool currently is increasing rapidly and starting to be used by various companies in the world to market their products. Do not be surprised if the text message now has a double function: as a messenger and also as a marketing tool.

An effective marketing tool is the key to success.? Only five years after the SMS was expressed as an important means of mobile communication; SMS has now become a legitimate marketing tool in the United States, Canada and many countries around the world.? This SMS is based on images and messages, both of which can be delivered in various ways. Marketing through online texting service is increasingly popular among the enterprises today. Therefore, it can be said that text messaging marketing has become the king in marketing technology.

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In this SMS generation, a mobile marketing technology promises great opportunities because the sms software offers a powerful marketing potential via direct communication with the target. While for the business owner, it is important for any company to get their ideas in a quick, brief and relevant format. Therefore, we can say that mass text is a procedure whereby certain messages are sent by the organization to the target groups of customers to convey product marketing.

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An effective marketing process will be followed by the different steps such as planning and executing the conception, pricing, marketing and distribution of the goods, services and ideas to meet the individual and organizational goals. Text messaging marketing has is a tendency to build a long term relationships with the people targeted.? This solution is useful for building the brand identity, such as send text message online is only a part of the whole scenario.

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Online texting service is the fastest way of marketing if compared with the other marketing tools. In this process, we can also use the sms gateway provider to generate the maximum promotion with the minimum possible cost. Online texting service is used to send and receive SMS messages without using a mobile phone. Therefore, this Text messaging marketing has been proven as the best solution for many large business firms and houses corporate to gain the success of their business.

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SMS marketing is the only one inexpensive way to promote goods and services to a variety of customer base. Therefore, the SMS sent should be brief, clear, easily understandable and interesting so that your message will be remembered by your potential customers easily.

Do you want to start your own business and make millions? sms software is one of the way for you to start making money. It is easy to start with low initial inverstment. There are a lot of text messaging marketing program out there, but to find the best one is hard. The good company should have feature such as send text message online, you will have more advantage than your competitors. Ask me if you have any question.

Source: http://www.asseenoncellphone.com/?p=710

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Dawn at Vesta: Massive mountains, rough surface, and old-young dichotomy in hemispheres

ScienceDaily (Oct. 3, 2011) ? NASA's Dawn mission, which has been orbiting Vesta since mid-July, has revealed that the asteroid's southern hemisphere boasts one of the largest mountains in the System. Other results show that Vesta's surface, viewed at different wavelengths, has striking diversity in its composition particularly around craters. The surface appears to be much rougher than most asteroids in the main asteroid belt. Preliminary results from crater age dates indicate that areas in the southern hemisphere are as young as 1-2 billion years old, much younger than areas in the north.

The findings are being presented at the EPSC-DPS Joint Meeting 2011 in Nantes, France.

"We are learning many amazing things about Vesta, which we call the smallest terrestrial planet," said Chris Russell, the Dawn Principal Investigator. "Like Earth, Mars, Venus and Mercury, Vesta has ancient basaltic lava flows on the surface and a large iron core. It has tectonic features, troughs, ridges, cliffs, hills and a giant mountain. The south polar mountain is larger than the big island of Hawaii, the largest mountain on Earth, as measured from the ocean floor. It is almost as high as the highest mountain in the solar system, the shield volcano Olympus Mons on Mars."

In mid July Dawn entered orbit around Vesta and began imaging what is possibly the oldest planetary surface in the solar system. The surface of Vesta shows the ravages of time. Many more craters are seen in the northern hemisphere than the southern because an enormous impact altered the earlier cratering record in the south. Since July the Dawn spacecraft has been moving ever closer to Vesta, moving into a polar orbit to look down on every square kilometre of the planetary surface. In mid August it entered Survey orbit at 2700 km altitude and mapped the entire sunlit surface with its framing camera and Visible and IR mapping spectrometer.

"We completed that phase at the beginning of September and since then have been moving the spacecraft to its next mapping orbit, the High Altitude Mapping Orbit at 680 km altitude, which it reached on the weekend. Over the coming month it will return complete coverage of the sunlit surface with a resolution of 60 metres," said Carol Raymond, Dawn's Deputy Principal Investigator.

A new coordinate system has been defined for Vesta because the old coordinate system, based on low-resolution telescopic data was wrong by almost 10?. Even with data from the Hubble Space Telescope it had been difficult to determine Vesta's rotation axis. After defining the coordinate system, the team has begun naming the prominent features.

"The head of the mapping spectrometer group, Angioletta Coradini, suggested that the large southern crater on Vesta be called Rheasilvia after the mother of Romulus and Remus and the mother of the Vestal virgins. The IAU has accepted this suggestion, as well as the names of thirteen Vestal virgins for craters that define quadrangles. The team is now measuring the craters, identifying ridges, hills and lineations to have the sunlit surface totally mapped by the end of the year," said Russell.

The Dawn framing camera, built and operated by the Max-Planck Institute for Solar System Research (MPS), in cooperation with DLR, Berlin and the Technical University of Braunschweig, provides more information than the black and white images suggest. The framing camera is equipped with seven colour filters in order to collect spectral information. This makes it possible to highlight certain spectral features in false colour maps that would not be visible to the naked eye. The surface of Vesta shows striking diversity when viewed in false colours that are ratios of light intensity at different wavelengths. These false colour variations are diagnostic of different surface materials. The spectral variations are particularly strong around craters. Where the clear filter images show bright and dark features, the colour data show these are also composed of different materials, likely excavated by the impacts.

"One of the most prominent colour features on Vesta's surface is associated with a 40 km diameter crater near Vesta's equator. It shows a spectacular red ejecta blanket to the south. We believe that this eject blanket, which covers only a half-circle, has been created by an impactor hitting the surface on a trajectory of oblique incidence," said Andreas Nathues of MPS.

Dawn also carries a Visible and Infrared Mapping Spectrometer (VIR), provided by the Italian Space Agency, and managed by Italy's National Institute for Astrophysics (INAF-IASF), in collaboration with Selex Galileo, where it was built. Data from VIR reveal the composition and nature of the materials on the surface of Vesta.

"Data from different wavelengths can be combined to investigate different types of materials. The colour variations seen by VIR suggest variability in the surface mineralogy. Brightness variations seen in visible light can be compared with the thermal emission at five microns to determine the source of the variations. Measured surface temperature variations range from 240 to 270K," said Maria Cristina de Sanctis, of INAF-IASF.

The difference in the number of craters between the two hemispheres is also striking. By counting the number of craters per unit area in different terrains, the relative ages of these different terrains can be obtained. Preliminary results of these crater age dates indicate much younger ages for areas in the south versus the north, as young as 1-2 billion years old. So far, the oldest ages, in the northern hemisphere, are younger than 4 billion years old, which is an unexpected result given that meteorites from Vesta have ages of 4 billion years. However, the crater counts will be refined with the more detailed data to be collected, and the assumptions about how the impact flux decays with time will be evaluated, so the absolute ages are preliminary.

"Vesta's surface has a surprisingly complex set of structural features, including the massive south polar mountain, steep slopes, deep troughs, and sets of curved lineations that appear in some cases to be associated with slumps, or landslides. The variation in Vesta's brightness as the sun angle changes indicates that the surface of Vesta is very rough, causing the light to scatter. This roughness could be at the scales of surface features or at the scale of individual minerals in the rocks, or both. Vesta's roughness is larger than most asteroids in the main asteroid belt," said Raymond.

"Tragically, the leader of the VIR spectrometer team, Angioletta Coradini, passed away last month but not before she got to see this amazing alien world and to see her suggestion to name the craters of Vesta after the Vestal virgins fulfilled. We are going to miss very much this amazing woman, brilliant scientist and esteemed leader of the VIR investigation," said Russell.

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Story Source:

The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Europlanet Media Centre, via AlphaGalileo.

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/10/111003093344.htm

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Communication to show for solo professionals-to six-way empathy ...

As a professional soloist and communication experts, I am often asked about the communication skills and a professional solo small business owners must have to be as effective as possible. Remain the best advice I can give is to the recipient, who say to the elegant way of communication, focusing on your customers and prospective customers' needs and desires is directed.

The most important thing to remember is to always keep in mind your account orPerspective. If you are paying more attention to your customers and prospects, and put yourself in their shoes, you are practicing empathy. And empathy is the most important communication skills a person can have is at work or at home. Themselves in the other place to get a feel for how it feels, with 20 emails in one week by the same person trying to sell something, are bombarded, for example. You will understand how it could take a while "to make a sale until the other person knowsYou and your company and you feel that is worthy of trust.

Empathy is different from sympathy. Sympathy says: "I understand". But empathy, says: "I feel your pain." And that's what people want. We want others to "get" us in a way that understanding can not be achieved alone. Here are some tips to help you to empathize with your customers and prospects:

1st Show them how you know where they are and tell them how you felt while you were in the same situation. Whether youSales of jewelry and virtual assistance services, you can probably relate to the problems of your customers in a very personal way.

2nd Stop listening to the sales and maintain.

3rd Never say never, under any circumstances: "I know how you feel." One can say: "I had something similar happen to me and when I heard the X. It 's how you feel?"

4th Remember the golden rule and then go one step further. Not only treat others the way you like to be treated, but the way they treat othersYou would want your mother, sister, best friend or another person, the most important and should be treated in your life. After all, these people (customers and prospective customers) so special that they may give you some of their hard earned money!

5th Try to look at the situation from his perspective, but as their own. What message would you / he will receive as a result of your actions or words?

6th Acknowledge the feelings of others "as often as possible. People have a right to feeltheir feelings, regardless of whether you agree with them or feel the same way. They ask, "How can I help?"

If you follow these simple guidelines, you will practice regularly and on your way to empathy. Once done, it is likely to be pleasantly surprised surprised by the results!

Source: http://business-solo-professionals.chailit.com/communication-to-show-for-solo-professionals-to-six-way-empathy-for-your-customers.html

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Bruxism Help Program, Health & Fitness

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Source: http://nlp.helplearn.info/health/43794-bruxism-help-program-health-fitness.html

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Bath And Shower Taps | News Vision

Bathroom renovations are all the rage in home improvement projects. The bath and the kitchen are the two areas of the house that are remodeled in most families. Your tub and shower tap is a key component to your overall look and design in your bathroom. Choosing the right fixture for your area is important and you do want to invest a little time to consider your options.There are tons and tons of this kind of product on the market. You can find one tub and shower tap after the next in stores like Home Depot and B+Q. This object comes in a wide variety of styles made out of a number of different materials. It is helpful if you become familiar with the different styles and materials before searching for the tub and shower tap for your home improvement project.A bathroom renovation can be a daunting task and you want things to progress quickly and smoothly. There are so many things to think about when engaged in such a home improvement project that a tub and shower tap may not be on the top of your lists of things to do. The very process of finding the right fixture seems like a waste of time until you have completed other tasks in the bathroom renovation project.You may be surprised to discover that you can actually build your bath around the right tub and shower fixture. Shopping for an item like this can really help to make the process of organizing this home improvement project run smoothly. One way to weed out different bath fixtures is to decide whether you want a modern look or a vintage style in the area. Simply choosing between modern and vintage bathroom decor can help you focus on organizing your materials for the project. If you are going for a modern look a single handle tub and shower tap is probably the right choice for the project. Choosing a material like chrome for the item would be perfect. Chrome is ideal for modern looks because it is sleek and shiny in its mirror-like quality.Vintage bathrooms would not necessarily look right with the chrome single handle fixture. A three handle tub and shower tap is perfect for a traditional look. Choosing materials like brushed stainless steel or brass would be great for this classic design. The materials are important because they do have an air of antiquity.Once you have decided which tub and shower tap is right for your bathroom renovation you are well on your way to creating the perfect bath for your home.

Posted in Uncategorized

Source: http://newsvision.hooobo.com/2011/10/03/bath-and-shower-taps/

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Buy This Movie Or Legally Download It For Free: Your Call

PressPausePlayPressPausePlay, an award-winning documentary about our new digital culture, premiered at SXSW earlier this year. It is playing at film festivals and you can buy it on iTunes, Amazon, and other digital pay sites. If you don't want to pay for it, you can now download it via a torrent for free. This free option was essential to the filmmakers. As Seth Godin says in the film, ideas that are free spread faster. The movie examines the impact of today's technology advances on our culture and the digital artists, musicians, and filmmakers who create it. In the film, Godin says "there has never been a better time to be an artist." Taking a completely different view, technology pessimist, Andrew Keen, host of TechCrunch TV's "Keen On", says "we may well be on the verge of a new dark age... where the creative world is destroyed."

Source: http://feedproxy.google.com/~r/Techcrunch/~3/rC3ZesqR6Os/

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Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa

Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa

Friday, September 30, 2011

In a paper published in the October 2011 issue of Experimental Biology and Medicine, a team of researchers at Columbia University Medical Center led by Stephen Tsang, MD, Ph.D have achieved temporary functional preservation of photoreceptors in a mouse model for retinitis pigmentosa (RP) using novel bipartite gene therapy.

RP is a heterogeneous disorder characterized by progressive degeneration of rod photoreceptors (which mediate night vision) causing night blindness and eventually total blindness. About 36,000 cases of simplex and familial RP worldwide are caused by mutant phosphodiesterase (PDE6). Says Dr. Tsang,

"Victor McKusick's Mendelian Inheritance in Man catalog has approximately 4,000 genetic disease entries, but only 4 of these are already curable by gene-therapy approaches. This bipartite vector, which allows cell-specific delivery of both the normal gene and shRNA to knockdown other genes in the pathway, represents a strategy that may help cure many more retinal degenerations. Degeneration of rod photoreceptors also affects approximately 9 million Americans with age-related macular degeneration. Strategies to save photoreceptors in mouse models of RP may be applicable to that disease as well."

In spite of this high prevalence, the interplay between defective PDE metabolism and RP pathogenesis remains poorly understood. In several mouse models for RP, defects in the PDE6B enzyme result in increased levels of the signaling molecules cGMP (mediated by GUCY2E cyclase) and Ca2+ (mediated by the CNGA1 channel).

Several aspects of the EBM report are innovative. It not only tackles the lack of functional PDE6? (by augmenting function with conventional gene replacement), but simultaneously counteracts the central biochemical impact of that lost function by decreasing abnormally accumulated cGMP and Ca2+. Furthermore, they used a tissue-specific promoter to achieve cell-specific expression of the transduced genes, which is unusual for shRNA delivery.

The researchers at Columbia developed three different lentiviral vectors, each of them designed to deliver wild-type Pde6b cDNA and one of two shRNAs. One vector delivered the cDNA and GUCY2E shRNA to reduce cGMP levels; another vector delivered the wild-type cDNA and CNGA1 shRNA to reduce Ca2+ levels; the third delivered the cDNA and the Gucy2e shRNA with a tissue-specific promoter. The bipartite approach was conceived as a way to improve therapeutic efficacy over that of a single-therapy approach, which was tested in an earlier project from Dr. Tsang's lab. While the current project did not show improvement over their previous work, the researchers are optimistic that bipartite delivery may represent an important resource in future explorations of gene therapy in the eye and other tissues types.

Typical existing shRNA vector systems use the RNA polymerase III promoter, which is expressed in essentially all cell types, to drive expression of the transduced gene. However, expression of shRNA targeting GUCY2E in cone photoreceptors, which mediates color vision, would have unwanted and deleterious effects on vision. To achieve rod-specific expression of the shRNA, the researchers in this work embedded Gucy2e shRNA into the Pol II transcription unit of pre-miR34, which is expressed solely in rods. Similar methods can be used to target different tissues, so this method may have wide applicability.

The testing of shRNA therapeutic approaches in Pde6bH620Q mice should facilitate pre-clinical therapeutic evaluation of retinitis pigmentosa. Lessons learned from the proposed studies will eventually be translated into strategies for treatment trials in larger animal models of PDE6? deficiency, such as Irish Setter dogs, before seeing application in human therapeutics.

Dr. Steve Goodman, Editor-in-Chief of Experimental Biology and Medicine said, "Researchers at Columbia University Medical Center led by Stephen Tsang, MD, Ph.D have used a unique gene therapy approach to preserve photoreceptors and prolong functional vision in a mouse model of retinitis pigmentosa (RP). There work offers the promise of a future gene therapy cure for RP".

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Society for Experimental Biology and Medicine: http://www.sebm.org/

Thanks to Society for Experimental Biology and Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 56 time(s).

Source: http://www.labspaces.net/113900/Cell_specific_mechanism_based_gene_therapy_approach_to_treat_retinitis_pigmentosa

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